Ajit Varki Selected Research

N-glycolylneuraminic acid

1/2021	Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah-/-mdx Mice.
1/2021	Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis.
1/2019	From "Serum Sickness" to "Xenosialitis": Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc.
1/2018	Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.
10/2016	Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid.
1/2014	A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.
3/2012	LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion.
6/2010	Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose.
1/2009	Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.
12/2008	Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression.

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Ajit Varki Research Topics

Disease

30	Neoplasms (Cancer) 02/2021 - 02/2002
25	Inflammation (Inflammations) 01/2021 - 07/2002
15	Carcinoma (Carcinomatosis) 02/2021 - 02/2002
9	Infections 01/2020 - 02/2013
6	Atherosclerosis 11/2021 - 01/2018
5	Neoplasm Metastasis (Metastasis) 01/2007 - 02/2002
4	Fibrosis (Cirrhosis) 01/2021 - 10/2009
4	Thrombosis (Thrombus) 10/2011 - 01/2007
3	Gonorrhea 10/2020 - 12/2015
3	Human Influenza (Influenza) 07/2015 - 01/2003
2	Prostatic Neoplasms (Prostate Cancer) 02/2021 - 07/2011
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 10/2016
2	Typhoid Fever (Typhoid) 12/2017 - 12/2014
2	Muscular Dystrophies (Muscular Dystrophy) 01/2017 - 01/2014
2	Endocarditis 11/2016 - 09/2007
2	Pneumonia (Pneumonitis) 06/2013 - 05/2007
2	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 01/2013 - 01/2013
2	Mucinous Adenocarcinoma (Mucinous Carcinoma) 10/2011 - 09/2003
2	Eosinophilia 10/2011 - 05/2007
2	Airway Remodeling 11/2010 - 10/2009
2	Malaria 09/2009 - 09/2005
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	COVID-19 01/2021
1	Acidosis 01/2021
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021
1	Sepsis (Septicemia) 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 02/2020
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 02/2019
1	Hyperglycemia 01/2019
1	Serum Sickness 01/2019
1	Hypertension (High Blood Pressure) 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2018
1	Ovarian Neoplasms (Ovarian Cancer) 11/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Muscular Diseases (Myopathy) 01/2018
1	Endotoxemia 01/2017
1	Hearing Loss (Hearing Impairment) 01/2017
1	Insulin Resistance 01/2017
1	Amyloid Plaque 01/2017

Drug/Important Bio-Agent (IBA)

28	N-Acetylneuraminic Acid (Sialic Acid)IBA 02/2021 - 01/2003
21	Sialic Acid Binding Immunoglobulin-like LectinsIBA 02/2021 - 05/2006
19	AntibodiesIBA 11/2021 - 06/2006
14	Polysaccharides (Glycans)IBA 01/2021 - 02/2006
11	N-glycolylneuraminic acidIBA 01/2021 - 09/2005
10	LigandsIBA 01/2017 - 02/2002
8	Proteins (Proteins, Gene)FDA Link 02/2021 - 01/2008
8	SelectinsIBA 09/2007 - 02/2002
7	MucinsIBA 11/2021 - 02/2002
7	Sialic AcidsIBA 01/2021 - 01/2008
7	AntigensIBA 01/2019 - 12/2008
7	Heparin (Liquaemin)FDA LinkGeneric 10/2011 - 02/2002
6	L-SelectinIBA 10/2011 - 02/2002
5	P-SelectinIBA 02/2006 - 02/2002
4	Hemagglutinins (Hemagglutinin)IBA 01/2020 - 10/2009
4	AutoantigensIBA 01/2019 - 01/2011
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 05/2011
4	Immunoglobulin G (IgG)IBA 09/2013 - 05/2011
4	AllergensIBA 11/2010 - 05/2007
3	AcidsIBA 01/2021 - 05/2002
3	LipidsIBA 01/2019 - 05/2002
3	Thrombin FDA Link 10/2011 - 09/2003
2	LectinsIBA 01/2021 - 11/2014
2	Mannose (D-Mannose)IBA 01/2021 - 01/2018
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2009
2	Neuraminidase (Sialidase)IBA 01/2020 - 01/2017
2	AutoantibodiesIBA 01/2019 - 05/2011
2	CMPacetylneuraminate monooxygenase (CMP-N-acetylneuraminate monooxygenase)IBA 01/2019 - 01/2017
2	EpitopesIBA 01/2018 - 05/2011
2	Virulence Factors (Pathogenicity Factors)IBA 12/2017 - 12/2014
2	EnzymesIBA 09/2017 - 01/2008
2	Complement System Proteins (Complement)IBA 01/2017 - 05/2011
2	Biological ProductsIBA 07/2015 - 05/2002
2	Carrier Proteins (Binding Protein)IBA 11/2014 - 09/2005
2	Monoclonal AntibodiesIBA 04/2014 - 07/2011
2	Tumor Biomarkers (Tumor Markers)IBA 01/2014 - 05/2011
2	SialyltransferasesIBA 06/2013 - 07/2002
2	Intravenous Immunoglobulins (IVIG)FDA Link 01/2013 - 05/2011
2	OvalbuminIBA 10/2011 - 04/2009
2	Fibronectins (Fibronectin)IBA 10/2011 - 11/2010
2	CollagenIBA 11/2010 - 10/2009
2	GlycolipidsIBA 01/2009 - 02/2002
2	Thromboplastin (Tissue Factor)IBA 09/2007 - 09/2003
1	HMGB1 Protein (HMG1)IBA 01/2021
1	SialoglycoproteinsIBA 01/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2021
1	Divalent CationsIBA 01/2021
1	ZincIBA 01/2021
1	4-(4-sulfophenylazo)-2-mercuriphenol (SAMP)IBA 02/2020
1	InflammasomesIBA 01/2020
1	NLR ProteinsIBA 01/2020
1	CytokinesIBA 01/2019
1	GlycoconjugatesIBA 01/2019
1	Dystroglycans (Dystroglycan)IBA 01/2018
1	Amino Acids FDA Link 12/2017
1	EsterasesIBA 09/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	EstersIBA 01/2017
1	polysialic acidIBA 01/2017

Therapy/Procedure

7	Therapeutics 10/2020 - 02/2002
5	Immunotherapy 02/2020 - 01/2014